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AKT · ENT/Neck & thyroidlow yield

Neck lumps (branchial & thyroglossal cysts)

Congenital neck cysts — framework for the neck lump

Overview

A practical framework for the neck lump, anchored on the two classic congenital cysts: a THYROGLOSSAL cyst (midline, moves up with tongue protrusion/swallowing) and a BRANCHIAL cyst (lateral, anterior to sternocleidomastoid). The overriding rule: a persistent neck lump in an adult is malignancy/metastasis until proven otherwise.

Recognise

  • Thyroglossal cyst: MIDLINE, moves UP on tongue protrusion and swallowing (attached to the hyoid/tongue base), young patients
  • Branchial cyst: smooth lump at the ANTERIOR border of sternocleidomastoid (upper third), young adults, may get infected
  • Reactive lymph node: tender, mobile, resolves; the location and behaviour place the lump in a differential

Red flags

  • A persistent, firm, fixed neck lump in an ADULT (especially with smoking/alcohol, dysphagia, hoarseness, or an HPV risk) → metastatic head-and-neck cancer/lymphoma → 2-week-wait

Differentials & how to tell them apart

Metastatic lymph node (head & neck SCC)persistent firm node in an adult — find the primary (2-week-wait)
Lymphomarubbery nodes ± B symptoms
Reactive lymphadenitistender, mobile, resolves with the infection
Thyroid/salivary massmoves on swallowing (thyroid) or located over the gland (salivary)

Investigations

Ultrasound + FNA is the key initial work-up of a neck lump. Thyroglossal/branchial cysts are confirmed on imaging; a suspicious lump → 2-week-wait ENT, endoscopy, and look for a primary.

Management

Ultrasound + FNA to characterise; excise congenital cysts; 2-week-wait if suspicious

  1. 1Characterise the lump by location/behaviour and ultrasound + FNA. Congenital cysts (midline thyroglossal — moves on tongue protrusion; lateral branchial) → surgical excision.Gate: In an ADULT, a persistent neck lump is metastatic head-and-neck cancer or lymphoma until proven otherwise → ultrasound + FNA and 2-week-wait ENT, rather than assuming a benign cyst — congenital cysts are the young-patient diagnosis
  2. 2Thyroglossal cyst → Sistrunk procedure; branchial cyst → excision; malignant/lymphomatous nodes → oncology MDT after finding the primary.
Surgical excision (cyst)thyroglossal (Sistrunk procedure) / branchial cyst — definitive for the congenital cysts
Treat per diagnosisantibiotics for infected cysts/reactive nodes; oncological pathway for malignancy

Key points

Midline + moves on tongue protrusion = thyroglossal; lateral anterior to SCM = branchial. But in adults, treat a persistent neck lump as cancer until proven otherwise. Ultrasound + FNA is the workhorse.

Monitor & prognosis

Histology/cytology; recurrence after excision; cancer surveillance if malignant.

Excellent for congenital cysts; depends on diagnosis if malignant.

Source: NICE NG12; ENT UK