The drug atlas
ENT/ENT infection antibiotics

ENT infection antibiotics

also: sore throat penicillin · otitis media amoxicillin · sinusitis · malignant otitis externa

Overview

Antibiotics for ENT infections, in context — the sore-throat penicillin (and the avoid-amoxicillin/check-FBC pitfalls), otitis media, bacterial sinusitis and the malignant-OE emergency.

Mechanism

Pathogen-directed. Most ENT bacterial infection is Strep/H. influenzae/M. catarrhalis → penicillins; malignant OE is Pseudomonas → an anti-pseudomonal fluoroquinolone. (Full class mechanisms: Antimicrobials section.)

Indications

  • Bacterial tonsillitis/pharyngitis (Centor/FeverPAIN)
  • Acute otitis media (when indicated)
  • Bacterial / chronic rhinosinusitis
  • Malignant (necrotising) otitis externa
  • Peritonsillar abscess (quinsy)

The agents

Phenoxymethylpenicillin (penV)sore throat

7–10 days

First-line if Centor ≥3 / FeverPAIN ≥4; clarithromycin if penicillin-allergic.

Amoxicillinotitis media / sinusitis

5–7 days

AOM if <2y bilateral, otorrhoea, or systemically unwell / not settling.

Ciprofloxacinmalignant otitis externa

systemic

Anti-pseudomonal — skull-base osteomyelitis in diabetics/immunocompromised; urgent ENT + IV abx.

Doxycyclinechronic sinusitis

Option in chronic rhinosinusitis with polyps.

Adverse effects

Amoxicillin rash in EBV/glandular feverclassic

Avoid amoxicillin in sore throat — use penV (rash if the cause is EBV).

Agranulocytosis missed in the at-risk patientserious

If a sore-throat patient is on a DMARD or carbimazole → urgent FBC (could be neutropenic sepsis, not simple tonsillitis).

C. difficile / GI upsetcommon

Cautions & contraindications

Amoxicillin for undifferentiated sore throatall

EBV rash; penV preferred.

Aminoglycoside ear drops with a perforated TMall

Ototoxicity (see Ear drops card).

Interactions

  • Clarithromycin: CYP3A4 (statins, warfarin)

Monitoring & kinetics

Most AOM/sore throat are self-limiting — antibiotics only per criteria,Urgent FBC if sore throat on carbimazole/DMARD

Oral; IV anti-pseudomonal for malignant OE. See Antimicrobials for full pharmacology.

Source: NICE NG84 — Sore throat · NICE CKS — Otitis media / sinusitis