The drug atlas
Surgery & Perioperative/Vascular
Carotid endarterectomy
also: CEA · carotid surgery
Overview
Removal of carotid plaque to prevent stroke in symptomatic significant carotid stenosis.
Mechanism
Surgical removal of the atheromatous plaque from the carotid artery → reduces the source of emboli and future stroke risk. Done early after the index event for maximum benefit.
Indications
- Symptomatic carotid stenosis ~50–99% (after TIA/non-disabling stroke), ideally within 2 weeks
The agents
Endarterectomyopen
Standard.
Carotid stentingendovascular
Selected patients.
Adverse effects
Peri-operative strokeserious
Cranial nerve injury (e.g. hypoglossal)common
MI, neck haematomacommon
Cautions & contraindications
Asymptomatic / <50% stenosis / total occlusionall
Benefit limited.
Choosing it
Recent TIA or non-disabling ischaemic stroke, with ipsilateral carotid stenosis 50–99% on imaging.
Source: NICE — Stroke/TIA (NG128)